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Trends Journal of Sciences Research 2019, 4(4), 127-140. http://doi.org/10.31586/Hepatology.0401.01Received: July 26, 2019 Revised: September 1, 2019 Accepted: September 20, 2019 Published: September 22, 2019174 Views 163 Downloads PDF Full-text (1.265 MB) PDF Full-text (1.265 MB) PDF Full-text (1.265 MB) PDF Full-text (1.265 MB) PDF Full-text (1.265 MB) HTML Full-textAbstractFiguresIntroduction: Liver and kidney affection is a life-threatening disease caused by factors including drug-based treatment. Treatment based on methotrexate could result in liver and kidney damages. The study evaluates the preventive effects of Sorindeia juglandifolia leaves on methotrexate-induced liver and kidney impairment in rat. Methods: Healthy rats divided into 6[...] Read more.Introduction: Liver and kidney affection is a life-threatening disease caused by factors including drug-based treatment. Treatment based on methotrexate could result in liver and kidney damages. The study evaluates the preventive effects of Sorindeia juglandifolia leaves on methotrexate-induced liver and kidney impairment in rat. Methods: Healthy rats divided into 6 groups daily received distilled water, methotrexate (20 mg/kg), sub-cutaneous injection of L-carnitin (500 mg/kg) and methotrexate and the plant extract doses of 150, 250 and 350 mg/kg and methotrexate for 10 days. During treatment, body weight was recorded. At the end of the treatment, animals were sacrificed; venous blood were collected for haematological and biochemical analysis. Liver and kidney were collected for oxidative markers and histological examination. Results: The consecutive treatment of animals with plant extract and methotrexate showed a significant prevention of the body weight decrease and enhancement of the relative weight of liver and kidney. Sorindeia. juglandifolia extract also protected from the significant increase in transaminase activities, bilirubin and protein level, hypercholesterolemia, atherogenic index, and in the kidney from hypercreatininemia and the increase in serum urea level. The extract prevented the decrease of sodium level and glomerular filtration. Plant extract improved reactive oxygen species detoxification agents and protected from the histological disorganization of the liver and kidney tissues, observed in the MTX control. Conclusion: Sorindeia juglandifolia leaves extract expressed hepatorenal protective properties and could be useful to prevent liver and kidney damage induce by methotrexate. Full articleReferences
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[1]Ostapowicz, G., Fontana, R.J., Schiodt, F.V., Larson. A., Davron J.T., Steven, H.B., Timothy, M., Reish, J. (2002). Results of a Prospective Study of Acute Liver Failure at 17 Tertiary Care Centers in the United States. Annal International Medicine, 137, 947-954.[2]Cullough, P.A., Wolyn, R., Rocher, L.L., Levin, R.N., O’Neill, W.W. (1997). Acute renal failure after coronary intervention: incidence, risk factors, and relationship to mortality. American Journal of Medicine, 103, 368-375.[3]Marieb, E.N. (2008). Biologie humaine. Principes d’anatomie et de physiologie. Huitième édition. Canada : Pearson Education. 631-999. "In French "[4]Du Cheyron, D., Bouchet, B., Parienti, J.J., Ramarkers, M., Charbonneau P. (2005). The attributable mortality of acute renal failure in critically ill patients with liver cirrhosis. Intensive Care Medecine, 31, 1693-9.[5]Anaizi. N. (2007). Drug Therapy in Kidney Disease. Rocheste Institute of Technology, 10-20.[6]Gonwa, T.A., Wadei, H.M. (2013). Kidney Disease in the Setting of Liver Failure: Core Curriculum.American. Journal of Kidney Disease, 62(6), 1198-1212.[7]Moreau, R., Durand, F., Poynard, T., Duhamel, C., Cervoni, J. P., Ichaï, P., Abergel, A., Halimi, C., Pauwels, M., Bronowicki, J.P., Giostra, E., Fleurot, C., Gurnot, D., Nouel, O., Renard,.P., Rivoal, M., Blanc, P., Coumaros, D., Ducloux, S., Levy., Pariente, A., Perarnau, J. M., Roche, J, Scribe-Outtas, M., Valla, D., Bernard, B., Samuel, D., Butel, J. Hadengue, A., Platek, Lebrec, D., Cadranel, J. F. (2002). Terlipressin in Patients with Cirrhosis and Type 1 Hepatorenal Syndrome: A Retrospective Multicenter Study. Gastroenterology. 122 (4), 923-30.[8]Aashish, P., Tarun, S. and Pallavi, B. (2012). Drug-Induced Hepatotoxicity. Journal of Applied Pharmaceutical Science, 2 (5), 233-243.[9]Tousson, E., Zaki, T. Z., Walid, A.A, and Hamada, H. (2014). "Methotrexate-induced Hepatic and Renal Toxicity: Role of L-carnitin in Treatment.Biomedicine and Biotechnology, 2(4), 85-92.[10]Wong, F. (2011). Renal disease and liver. Clinics in Liver Disease, 15, 39-53.[11]Tousson, E., Hafez, E., Zaki, S., Gad, A. (2014).P53, Bcl-2 and CD68 expression in response to amethopterin-induced lung injury and ameliorating role of L-carnitin. Biomedical Pharmacotherapy, 68(5), 631-6399.[12]Tousson, E., Atteya, Z., El-Atrash, A., Jeweely, O.I. (2014). Abrogation by Ginkgo Byloba Leaf Extract on Hepatic and Renal Toxicity Induced by Methotrexate in Rats. Journal of Cancer Research and Treatment, 2 (3), 44-51.[13]Iyyaswamy A, Rathinasamy S. (2012). Effect of chronic exposure to aspartame on oxidative stress in the brain of albino rats. J Biosci. 37: 679-688.[14]Ozogula, B., Kisaoglua, A., Turanb, M.I., Altunerc, D., Senerd, E., Cetine, N., Ozturk, C. (2013). The effect of mirtazapine on methotrexate induced toxicity in rat liver. Science Asia, 39, 336-356.[15]Henghe, Tian., M.D., and Bruce, N. Cronstein, M.D. (2007). Understanding the Mechanisms of Action of Methotrexate: Implications for the Treatment of Rheumatoid Arthritis. Bulletin of the NYU Hospital for Joint Diseases, 65(3),168-73.[16]Merill, J.T., Shen, C., Schreibman, D., et al. (1997). Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Arthritis Rheumatoid, 40(7), 1308-15.[17]Chan, E.S., Montesinos, M.C, Fernandez, P., et al. (2006). Adenosine A (2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Journal of Pharmacology, 148(8), 1144-55.[18]Harborne, J.B. (1976).Phytochemical methods : a guide to modern techniques of plant analysis. London: Chapman and Hall.[19]Odebiyi O., Sofowora E. (1979). Antimicrobial alkaloids from a nigerian chewing stick (Fagara zanthoxyloides), Journal of Medicinal Plants Research,36, 204–207.[20]Evans, W.C., Trease, G.E. (1989). Trease and Evans’ pharmacognosy. 13th ed. London; Philadelphia: Bailliere Tindall.[21]Sofowara A. (1993). Medicinal plants and traditional medicine in Africa. 2nd ed. Nigeria: Limited Ibadan; 1993.[22]Chauhan, P., Sharma, H., Singh, S., Gupta, Y. K. , Kumar, U. (2018). . Attenuation of methotrexate-induced hepatorenal damage by Terminalia bellerica fruit extract in experimental rats. Pharmacognosy research, 10 (3), 301-308.[23]Rajagopalan, P.T.R., Zhang, Z., McCourt, L., Dwyer, M., Benkovic, S.J., Hammes, G. G. (2002). "Interaction of dihydrofolate reductase with methotrexate: Ensemble and single-molecule kinetics". Proceding. Natl. Academic. Science. 99 (21): 13481–6.[24]Goodsell, D.S. (1999). . The Oncologist. 4 (4): 340–1.[25]Hursting, S.D., DiGiovanni, J., Dannenberg, A.J., Azrad, M., LeRoith, D., Wendy Demark-Wahnefried, W., Kakarala, M., Angela Brodie, A., Berger, N.A. (2012). Obesity, Energy Balance, and Cancer: New Opportunities for Prevention. Cancer Prevention Research, 5(11): 1260–72.[26]Iwalokun, B., Efedede, B., Alabi-Sofunde, J., Oduala, T., Magbagbeola, O., Akinwande, A., (2006). Hepatoprotective and antioxidant activities of Vernoniaamygdalinaon acetaminophen-induced hepatic damage in mice. Journal of Medicinal Food, 9 (4), 524-530.[27]Di Carlo, G., Mascolo, N., Izzo, A.A. Capasso, F. (1999). Flavonoids: old and new aspects of a class of natural therapeutic drugs. Review Life Science, 65, 337-353.[28]Nkhili, E. (2004). Polyphénols de l’Alimentation : Extraction, Interactions avec les ions du Fer et du Cuivre, Oxydation et Pouvoir antioxydant. Diplôme de Doctorat, Spécialité : Sciences des Aliments. Université Cadi Ayyad. Marrakech Université d’avignon et des Pays de Vaucluse Ecole Doctorale 306-SPSA, Montpellier. 378 p.[29]Sotoudehmanesh, R., Anvari, B., Akhlaghi, M., Shahraeeni, S., Kolahdoozan, S. (2010). Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis. Middle East.Journal of Digestive Diseases, 2, 104-9.[30]Gaies, E., Jebabli, N., Trabelsi, S., Salouage, I., Charfi, R., et al. (2012). Methotrexate side effects. Journal of Drug Metabolism and Toxicology, 3:4, 1-5.[31]Turan Y., Ahmet, U., Mehmet, S.K., Ömer, F.K., Baris, A.U., Zabit, Y. (2018). Protective effects of silymarin on methotrexate-induced damages in rat testes. Brazilian. Journal of Pharmaceutical Science, 2018, 54(1), 1-10.[32]Sabah, N.A. and Yasmin, L.A. (2013). Effect of Methotrexate on the Liver Enzymes and Lipid Profile in Adult Female Albino Mice. Baghdad Science Journal, 10(1), 176-181.[33]Bauer, J.E (1996). Hepatic disease, nutritional therapy, and the metabolic environment. Journal of the American veterinary medical association, 209, 1850-1853.[34]Soni, K.B., Kuham, R. (1992). Effect of oral curcumin administration on seruparoxides and cholesterol levels in human volunteers. Indian Journal of physiology. Pharmacology, 36(4):273-5[35]Shishikura, Y., Khokhar S., et al. (2006). "Effects of Tea Polyphenols on Emulsification of Olive Oil in a Small Intestine Model System. Journal of Agricultural and Food Chemistry, 54(5), 1906-1913.[36]Salvador, L.G. and Magdalena, M. (2015). Biomarkers in chronic kidney disease, from kidney function to kidney damage. World Journal of Nephrology. 4(1): 57-73.[37]Perazella, M.A. (1999). Crystal-induced acute renal failure. American Journal of Medecine, 106(4), 459-65.[38]Hoang-Xuan, K., Taillandier, L., Chinot, O., Soubeyran, P., Bogdhan, U., Hildebrand, J., et al. (2003). Chemotherapy alone as initial treatment for primary CNS lymphoma in patients older than 60 years: a multicenter phase II study (26952) of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Journal of Clinical Oncology, 21(14), 2726-31.[39]Deray, G., Khayat, D., Cacoub, P., Bourbouze, R., Musset, L., Baumelou, A., et al. (1989). The effects of diltiazem on methotrexate-induced nephrotoxicity. European Journal of Clinical Pharmacology, 37(4), 337-340.[40]Briot, K., Audran, M., Cortet, B., Fardellone, P., Marcelli, C., Orcel, P., et al. (2009). Vitamine D : Effet osseux et extra osseux ; recommandations de bon usage. Presse Medecine. 38(1): 43-54. "In French"[41]Dusso, A.S., Brown, A.J., Slatopolsky, E. (2005). Vitamin D. American Journal of Physiology Renal Physioogy, 289: 8-28.[42]Tobias, H., Auerbach, R. (1973). Hepatotoxicity of long-term methotrexate therapy for psoriasis. Archives International Medecine, 132, 391-396.[43]Martin, P. Y., P., Ginès, R., Schrier. (1998). « Nitric oxide as a mediator of hemodynamic abnormalities and sodium and water retention in cirrhosis » The New. England. Journal of Medecine, 339 (8), 533-41.[44]Epstein, M. (1994). « Hepatorenal syndrome: emerging perspectives of pathophysiology and therapy. Journal of. American Society. Nephrology, 4 (10), 1735-1753.[45]Ginès, P., Arroyo, V. (1999). "Hepatorenal syndrome". Journal of American Society Nephrology, 10 (8), 1833-9.[46]Arroyo, V., Jimenez, W. (2000). Complications of cirrhosis. Renal and circulatory dysfunction. Lights and shadows in an important clinical problem. Journal of Hepatology, 32 (1), 157-70.[47]Fabjan, N., Rode, J., Kosir, I.J., Wang, Z., Zhang, Z., Kreft, I.(2003). Tartary buckwheat (FagopyrumtataricumGaertn) as a source of dietary rutin and quercitrin. Journal of Agriultural and Food Chemistry, 51(22), 6452-64525.[48]Bruneton, J. (2009). Pharmacognosie, phytochimie, plantes médicinales. 4èmeed Paris. Tec & doc. Lavoisier "In French"[49]Marunaka, Y. (2014). Characteristics and pharmacological regulation of epithelial Na+ channel (ENaC) and epithelial Na+ transport. Journal of Pharmacology Science, 126, 21-36.[50]Sulaiman, M., Matta, M.J., Sunderesan, N.R., Gupta, M.P., Periasamy, M., Gupta, M. (2010). Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improvescardiac function in diabetic cardiomyopathy. American Journal of Physiology Heart Circulatory Physiology, 298, 833-843.[51]Parthasarathy, D.K., Bryan, N.S. (2012). Sodium nitrite: The “cure” for nitric oxide insufficiency. Meat Science, 92 (3), 455-500.[52]Valko, M., Leibfritz, D., Moncol, J., Cronin, T., Mazur, M., Telser, J., (2007). Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology, 39 (1), 44-84.[53]Coleshowers, C.L., Oguntibeju, O.O., Ukpong, M., Truter, E.J. (2010).[54]Saka, S.Aouacheri, O. (2017).The Investigation of the Oxidative Stress- Related Parameters in High Doses Methotrexate-Induced Albino Wistar Rats. Journal of bioequivalent and Bioavailability, 9, 372-376.[55]Al-Amiery, A.A., Kadhum, A.A.H, Mohamad, A.B, Musa, A.Y., Li, C.J. (2013). Electrochemical study on newly synthesized chlorocurcumin as an inhibitor for mild steel corrosionin hydrochloric acid. Materials, 6(12), 5466-77.[56]Hadjipavlou L, D., Kontogiorgis, C., Pontiki, E., Dakanali, M., Akoumianaki, A., Katerinopoulos, H.E. (2007). Anti-inflammatory and antioxidant activity of coumarins designed as potential fluorescent zinc sensors. Journal of Enzyme Inhibition and Medicinal Chemistry, 22(3), 287-92.[57]Benaissa, O. (2011). Etude des métabolismes terpénique et flavonique d’espèces de la famille des composées, genres Chrysanthemum et Rhantherium. Activité Biologique. Thèse Doctorat, université Mentouri Constantine. 63p. In french[58]Fraga C. G, Galleano M et al. (2010). "Basic biochemical mechanisms behind the health benefits of polyphenols." Molecular Aspects of Medicine. 31(6): 435-445.