Research Article

Aqueous Extract of Sorindeia Juglandifolia Leaves Protects Methotrexate-Induced Liver and Kidney Damage in Rat

Table 4

Effect of aqueous extract of Sorindeia juglandifolia on some oxidative stress parameters in liver and kidney tissues of animals.

  Catalase (µmol of H2O2/g of organ) Glutathione (µmol/g of organ) SOD (unit of SOD/g of organ) Nitrites (µmol/g of organ) Protein tissue (mg/dL) MDA (µM/g of organ)

Liver

Neutral control 3.17±0.10 12.85±0.37 10.28±0.11 659.99±29.48 0.81±0.02 1.46±0.19

MTX control 2.62±0.03 3.18±1.68≠≠≠ 8.13±0.12≠≠≠ 510.74±24.02≠≠≠ 0.39±0.02≠≠≠ 6.41±0.75≠≠≠

L-carnitin 3.30±0.11ααα 11.10±0.91ααα 10.30±0.13ααα 617.98±2.18αα 0.80±0.02αα 1.67±0.20ααα

S.jug150 mg/kg 3.62±0.10ααα 3.92±0.17≠≠≠*** 8.91±0.11 546.33±26.42 0.54±0.02≠* 2.92±0.21ααα

S.jug250 mg/kg 3.62±0.10ααα 3.92±0.17≠≠≠*** 8.91±0.11 546.33±26.42 0.54±0.02≠* 2.92±0.21ααα

S.jug350 mg/kg 3.75±0.11ααα 10.84±0.62ααα 9.98±0.11 531.05±36.57 0.75±0.02αα 0.42±0.04ααα

Kidney

Neutral control 3.39±0.54 29.95±1.74 8.22±0.21 635.53±29.48 0.50±0.02 2.80±0.34

MTX control 2.46±0.02≠≠ 4.96±2.48≠≠≠ 6.79±0.13≠≠≠ 477.39±25.03≠≠≠ 0.14±0.02≠≠≠ 5.80±0.44≠≠≠

L-carnitin 2.81±0.08 14.91±1.49≠≠≠ααα 8.01±0.22 611.81±13.10ααα 0.49±0.09 ααα 3.02±0.77ααα

S.jug150 mg/kg 3.00±0.09α 8.33±1.14≠≠≠*** 7.26±0.13 562.39±2.18 0.23±0.02≠≠* 2.12±0.45ααα

S.jug250 mg/kg 3.00±0.13α 16.38±1.66≠≠≠ααα 7.70±0.11 609.58±24.02 0.46±0.14αα** 2.14±0.41ααα

S.jug350 mg/kg 2.87±0.07 17.41±1.53≠≠≠ααα 7.74±0.10 524.09±24.11 0.32±0.02 2.23±0.45ααα