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Research Article Open Access
Chia-Man Chou, Sheng-Yang Huang, Chou-Ming Yeh, Hou-Chuan Chen
Trends Journal of Sciences Research 2019, 4(4), 141-147. DOI: 10.31586/Urology.0404.02
Published: November 7, 2019
407 Views  81 Downloads 
Abstract
Introduction: Hypospadias repair is a challenging technique in pediatric urology with a long learning curve. This study presents the results of urethroplasty performed by a single surgeon to repair hypospadias in children and compares the surgical outcomes at different periods. Materials and Methods: From January 2009 to February 2016, patients
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Introduction: Hypospadias repair is a challenging technique in pediatric urology with a long learning curve. This study presents the results of urethroplasty performed by a single surgeon to repair hypospadias in children and compares the surgical outcomes at different periods. Materials and Methods: From January 2009 to February 2016, patients who were less than 18 years old and were operated for hypospadias were retrospectively reviewed and divided into two groups: group I (from January 2009 to February 2012) and group II (from March 2012 to February 2016). All operations were performed by the same pediatric surgeon, and surgical outcomes of the two periods were compared. Results: This study considered150 patients (69 in group I/81 in group II). The Mean operative age was 30.4±32.7 months in group I and 33.6±43.3 months in group II(p=0.309). The selected procedures mainly depended on the subjective anatomical analysis in the operating room and the surgeon’s preference. The mean follow-up duration was 21.7±28.31 months in group I and 13.6±16.6 months in group II (p=0.033).The overall complication rate was 44.9% in group I and 35.8% in group II (p=0.316). The incidence of glanular disruption significantly decreased from 21.7% to 6.2% (p=0.007) because of the wide dissection of the glanular wings and the deep incision of the urethral plate, which led to tension-free sutures for glanular reconstruction. Conclusions: One-stage repair of hypospadias may achieve satisfactory outcomes in cosmetic appearance and voiding function. Surgical outcomes could be improved by increasing practice.Full article
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Research Article Open Access
Wendja Nnouck Monique Alide, Gounoue Kamkumo Raceline, Ngueguim Tsofack Florence, Dzeufiet Djomeni Paul Désiré, Massa Zibi Benoît, Fouda Bekono Yannick, Dimo Théophile
Trends Journal of Sciences Research 2019, 4(4), 127-140. DOI: 10.31586/Hepatology.0401.01
Published: September 22, 2019
212 Views  127 Downloads 
Abstract
Introduction: Liver and kidney affection is a life-threatening disease caused by factors including drug-based treatment. Treatment based on methotrexate could result in liver and kidney damages. The study evaluates the preventive effects of Sorindeia juglandifolia leaves on methotrexate-induced liver and kidney impairment in rat. Methods: Healthy rats divided into 6
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Introduction: Liver and kidney affection is a life-threatening disease caused by factors including drug-based treatment. Treatment based on methotrexate could result in liver and kidney damages. The study evaluates the preventive effects of Sorindeia juglandifolia leaves on methotrexate-induced liver and kidney impairment in rat. Methods: Healthy rats divided into 6 groups daily received distilled water, methotrexate (20 mg/kg), sub-cutaneous injection of L-carnitin (500 mg/kg) and methotrexate and the plant extract doses of 150, 250 and 350 mg/kg and methotrexate for 10 days. During treatment, body weight was recorded. At the end of the treatment, animals were sacrificed; venous blood were collected for haematological and biochemical analysis. Liver and kidney were collected for oxidative markers and histological examination. Results: The consecutive treatment of animals with plant extract and methotrexate showed a significant prevention of the body weight decrease and enhancement of the relative weight of liver and kidney. Sorindeia. juglandifolia extract also protected from the significant increase in transaminase activities, bilirubin and protein level, hypercholesterolemia, atherogenic index, and in the kidney from hypercreatininemia and the increase in serum urea level. The extract prevented the decrease of sodium level and glomerular filtration. Plant extract improved reactive oxygen species detoxification agents and protected from the histological disorganization of the liver and kidney tissues, observed in the MTX control. Conclusion: Sorindeia juglandifolia leaves extract expressed hepatorenal protective properties and could be useful to prevent liver and kidney damage induce by methotrexate.Full article
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Research Article Open Access
Xinjie Ning, Juncheng Luo, Gengqiang Ling, Xiaochun Zhong, Shoulian Zheng, Jian Guo, Qingchang Liu, Binchu Xu
Trends Journal of Sciences Research 2019, 4(3), 121-126. DOI: 10.31586/Cancer.0403.05
Published: August 24, 2019
183 Views  133 Downloads 
Abstract
Background and objective: Glioblastoma (GBM) is one of the malignant tumors causing death worldwide. Most patients were found in the middle and late stages and had poor prognosis. The purpose of this study was to investigate the expression and significance of CTSC in GBM. Methods: The information about CTSC in
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Background and objective: Glioblastoma (GBM) is one of the malignant tumors causing death worldwide. Most patients were found in the middle and late stages and had poor prognosis. The purpose of this study was to investigate the expression and significance of CTSC in GBM. Methods: The information about CTSC in Oncomine database was collected and analyzed twice. The role of CTSC in GBM was meta-analyzed. The expression of CTSC in glioma cell lines was retrieved by CCLE database, and the survival of patients was analyzed by TCGA database. Results: A total of 1,459 different types of CTSC were collected in Oncomine database, 134 of which had statistical differences in CTSC expression, 89 of which had increased CTSC expression and 45 of which had decreased CTSC expression. A total of 50 studies involving the expression of CTSC in GBM cancer and normal tissues included 1,189 samples. Compared with the control group, CTSC was highly expressed in GBM (P < 0.05). Moreover, CTSC was highly expressed in glioma cell lines. There was a correlation between the expression of CTSC and the overall survival rate of GBM. The overall survival rate of patients with high expression of CTSC was worse, while the prognosis of patients with low expression of CTSC was better (P < 0.05). Conclusion: Through the in-depth mining of oncomine gene chip database, we propose that CTSC is highly expressed in GBM tissues and is related to the prognosis of GBM, which may provide an important theoretical basis for the treatment of glioma..Full article
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Research Article Open Access
Hamza Badamasi, Muhammad Saminu Dagari
Trends Journal of Sciences Research 2019, 4(3), 111-120. DOI: 10.31586/Chemistry.0403.04
Published: June 24, 2019
179 Views  136 Downloads 
Abstract
Abiotic stress especially due heavy metals is one of the major environmental problems that threatens food security and pose greater risks to human health worldwide. In this research, greenhouse hydroponic experiments were carried out to study the morphological and biochemical responses of Sorghum bicolor L.M to different Zinc (Zn) levels.
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Abiotic stress especially due heavy metals is one of the major environmental problems that threatens food security and pose greater risks to human health worldwide. In this research, greenhouse hydroponic experiments were carried out to study the morphological and biochemical responses of Sorghum bicolor L.M to different Zinc (Zn) levels. Two-week-old seedlings transplanted in hydroponic solutions were treated with different doses of Zn in the concentration ranges of 5, 25, 50, 100 and 200 mg/L supplied as ZnSO4. 5H2O. After 21 day of culture, the plants were harvested, blotted to dryness and separated into roots and shoots. The root and shoot lengths, dry weights and non-enzymatic biochemical parameters such as proline, Chlorophyll a, b, Carotenoids (pigments) were determined. The results indicate that Zn applications significantly (P<0.05) depressed the lengths of root and shoot, dry weights and pigment contents compared to untreated plants (control). The effects were more pronounced with increased Zn dosage. The accumulation of the metal and proline contents in treated plants however, increase gradually with increasing Zn concentrations (P<0.05). The changes in these parameters had resulted in toxicity symptoms and overall growth retardation especially at elevated concentrations and the estimated critical toxicity thresholds in both solution and tissue concentrations suggest that sorghum bicolor L.M should not be grown beyond Zn concentration of above 3.2 mg/L.Full article
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Research Article Open Access
Zhiping Li, Liping Lei, Jianhua Gong, Junyi Wang, Bo Li, Chunmei Zhou, Jiangfa Li
Trends Journal of Sciences Research 2019, 4(3), 106-110. DOI: 10.31586/Cancers.0403.03
Published: March 1, 2019
321 Views  240 Downloads 
Abstract
Objective: This study aimed to determine whether perioperative antiviral treatment is facilitate for patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and Child-Pugh grade A cirrhosis in perioperative recovery of liver function and HBV activation. Methods: The study included 115 patients with HBV-related HCC and Child-Pugh grade A cirrhosis
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Objective: This study aimed to determine whether perioperative antiviral treatment is facilitate for patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and Child-Pugh grade A cirrhosis in perioperative recovery of liver function and HBV activation. Methods: The study included 115 patients with HBV-related HCC and Child-Pugh grade A cirrhosis who underwent resection. Patients were prospectively assigned to a preoperative antiviral treatment group (n = 51) or postoperative antiviral treatment group (n = 52); twelve patients who had not received antiviral treatment before and after surgery were designated a non-treatment group (n = 12). HBV reactivation during a month after the operation was defined as a HBV DNA value tenfold over preoperative values. Postoperative liver dysfunction was defined as prothrombin activity <50% and serum bilirubin >50 mmol/L on postoperative day 5. Results: Postoperatively, liver dysfunction was present in 1 of 51 (1.96%) patients who received preoperative antiviral therapy, 1 of 52 (1.92%) who received postoperative therapy, and 3 of 12 (25%) who received no antiviral therapy. HBV reactivation postoperatively occurred at similar rates. Conclusions: Preoperative and postoperative antiviral treatment of patients with Child-Pugh grade A cirrhosis and high levels of HBV DNA undergoing hepatic resection for HCC are both facilitate in preventing perioperative liver dysfunction and reactivation of HBV. Thus, in this population with high levels of HBV DNA, perioperative antiviral treatment is important.Full article
Research Article Open Access
Joseph Anejo-Okopi, Ocheme Julius Okojokwu, Nenkimwa Adamu, Juliet Ogbonna, Joshua Adetunji, Gabriel Odugbo Ikwulono
Trends Journal of Sciences Research 2019, 4(3), 99-104. DOI: 10.31586/Microbiology.0403.02
Published: March 1, 2019
382 Views  263 Downloads 
Abstract
Human immunodeficiency virus (HIV) infection is associated with an increased risk for Viral infections such as Epstein-Barr virus (EBV)infections also known as Human Herpes Virus Type 4 (HHV-4) and their related diseases which frequently cause malignancy related diseases resulting to poor treatment and health outcomes. In this study, we determined
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Human immunodeficiency virus (HIV) infection is associated with an increased risk for Viral infections such as Epstein-Barr virus (EBV)infections also known as Human Herpes Virus Type 4 (HHV-4) and their related diseases which frequently cause malignancy related diseases resulting to poor treatment and health outcomes. In this study, we determined the seroprevalence of EBV VCA IgM antibodies among HIV patients attending Plateau Specialist Hospital, Jos, Nigeria and to evaluate their association with age, sex as well as other demographic factors. A total of 92 HIV positive patients were enrolled and serum samples were screened for antibodies using the ELISA kit. The prevalence of EBV VCA IgM was 6/92(6.53%), and mean age of 37.48 ±1.01 years. This study has contributed to baseline data, and suggest the need for larger studies and importance of screening and treatment of EBV among HIV patients.Full article
Research Article Open Access
A. L. C. Ribeiro, F. C. S. Teixeira, E. De Paiva
Trends Journal of Sciences Research 2019, 4(3), 88-98. DOI: 10.31586/Radiology.0403.01
Published: March 1, 2019
374 Views  259 Downloads 
Abstract
The number of cases of cancer has significantly increased in the world and the use of ionizing radiation produced by large clinical linear accelerators plays an important role in the treatment of tumors. Although radiotherapy is considered a safe medical practice, it may bring some risks for the patient and
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The number of cases of cancer has significantly increased in the world and the use of ionizing radiation produced by large clinical linear accelerators plays an important role in the treatment of tumors. Although radiotherapy is considered a safe medical practice, it may bring some risks for the patient and in some extreme cases even her/his death. Over the last decades, the learning with incidents there has been a powerful way to prevent them to turn to happen. In this work a digital tool was developed for recording and evaluation of incidents in external beam radiation therapy. The tool was designed to function in an intranet environment, but it can also be used in the offline mode and is based on a set of sequential forms filled by the user (e.g. medical physicists, medical dosimetrists, radiation oncologists, radiotherapy technicians). The software was firstly applied in a radiation oncology department of a public Institution in Rio de Janeiro, Brazil. The software has proved to be an important and promising tool to improve the healthcare quality of patients undergoing radiation therapy.Full article
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Research Article Open Access
Yulitha Barnabas, Pilly Machivya, Sixbert I. Mkumbaye
Trends Journal of Sciences Research 2019, 4(2), 80-87. DOI: 10.31586/InfectiousDiseases.0402.05
Published: February 1, 2019
210 Views  160 Downloads 
Abstract
Background: Anemia is the most frequent hematologic abnormality of HIV disease and one of the most common manifestations of nutritional deficiency disorders in the world. In sub-Saharan Africa, about 70% of the world’s people living with HIV/AIDS, where the prevalence of anemia is higher than in developed countries. The aim
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Background: Anemia is the most frequent hematologic abnormality of HIV disease and one of the most common manifestations of nutritional deficiency disorders in the world. In sub-Saharan Africa, about 70% of the world’s people living with HIV/AIDS, where the prevalence of anemia is higher than in developed countries. The aim of this study was to determine the prevalence and factors associated with anemia among people living with HIV at Dodoma regional hospital during 2013-2014. Methodology: A retrospective cross-section study conducted among PLWHIV at Dodoma Regional Hospital between 2015 and 2016. A total of 869 PLWHIV were enrolled. Data extraction sheet were used to collect Socio- demographics, immune-hematological data and ARV status from existing patient’s files (CTC 2 card). Double entry of data in Microsoft excel were done and transferred for analyzing using SPSS v.16. Results: Majority of them were females 648(74.6%)and 508(58.2%) were between 19-45years with mean age of 38.84(±14.09). 824(94. 8%) were on ARV; where 640(73.6%) are from urban. The overall prevalence of anaemia among PLHIV was 59.5% of which 56.6% of these were on ARV, and 2.9% were not on ARV. Age, sex and CD4+ counts < 200cell/µl were among factors associated with anemia among PLWHIV. Conclusion: Moderate anaemia was common in the study population. Screening and management of anemia along with the proper use Anti-retroviral therapy may decrease risk of anemia and the effect ARV on red blood cells. Haemoglobin measurements should be taken before initiation of ARV and routinely followed among ARV users.Full article
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Research Article Open Access
Refat Hassan, Samia Ibrahim
Trends Journal of Sciences Research 2019, 4(2), 68-79. DOI: 10.31586/Chemistry.0402.04
Published: February 1, 2019
251 Views  185 Downloads 
Abstract
The kinetics and mechanism of oxidation of methyl cellulose (MC) polysaccharide by hexacholroiridate (IV) in aqueous perchlorate solutions at a constant ionic strength of 0.1 mole dm-3 has been investigated, spectrophotometrically. The experimental results showed first-order dependence in [IrCl6]2- and fractional first-order kinetics with respect to the MC concentration. The
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The kinetics and mechanism of oxidation of methyl cellulose (MC) polysaccharide by hexacholroiridate (IV) in aqueous perchlorate solutions at a constant ionic strength of 0.1 mole dm-3 has been investigated, spectrophotometrically. The experimental results showed first-order dependence in [IrCl6]2- and fractional first-order kinetics with respect to the MC concentration. The reaction rate was found to increase with decreasing the [H+]. A kinetic evidence for formation of 1:1 intermediate complex was revealed. The reaction kinetics seems to be of considerable complexity where one chloride ion from hexacholoiridate (IV) oxidant may act as a bridging ligand between the oxidant and the substrate within the formed intermediate complex. However the added chloride ions and oxidation products were found to have negligible effects on the reaction rate, the added acrylonitrile indicated the intervention of free-radical mechanism during the oxidation process. The kinetic parameters have been evaluated and a tentative reaction mechanism consistent with the kinetic results is discussed.Full article
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Research Article Open Access
Monia Deghrigue Abid, Sirine Lajili, Hiba Hadj Ammar, Dora Cherif, Nejeh Eltaief, Hatem Majdoub, Abderrahman Bouraoui
Trends Journal of Sciences Research 2019, 4(2), 62-67. DOI: 10.31586/Pharmacology.0402.03
Published: February 1, 2019
285 Views  177 Downloads 
Abstract
Polysaccharides are known to have interesting biological activities. To date polysaccharides extracted from Tunisian seaweed have not been fully studied. In this paper we tried to isolate sodium alginate from two brown algae and evaluate their biological activities. Two brown seaweeds Dictyopteris membranaceae and Padina pavonica were treated with selective
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Polysaccharides are known to have interesting biological activities. To date polysaccharides extracted from Tunisian seaweed have not been fully studied. In this paper we tried to isolate sodium alginate from two brown algae and evaluate their biological activities. Two brown seaweeds Dictyopteris membranaceae and Padina pavonica were treated with selective solvents to extract sodium alginate. Analyses were performed to determine their IR spectra, uronic acid’s content and biological properties (antioxidant and gastroprotective activities). Results showed that sodium alginate extracted from D. membranaceae contained 65% of uronic acid while this extracted from P. pavonica contained only 9% of uronic acid. These polysaccharides showed also variation in the structure and the activities. Sodium alginate extracted from D. membranaceae had the highest antioxidant activity with ED50 of 20µg/ml in the DPPH test. Additionally, this polysaccharide had the most important gastroprotective activity with a percent of 97% at dose 50mg/kg. Our finding suggested that sodium alginates extracted from D. membranaceae and P. pavonica could be used as a natural source of antioxidant and gastroprotective agents.Full article
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