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Keywords = Biochemistry

  • Open Access Research Article
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    Trends Journal of Sciences Research 2014, 1(1), 38-48. http://doi.org/10.31586/Biochemistry.0101.06
    18 Views 220 Downloads 1 Citations PDF Full-text (962.717 KB)  HTML Full-text
    Abstract
    The biological activity of chemical compounds is analyzed using electronic and information factors. We found a linear interrelation between the electronic and information factors of molecules. Moreover, these molecular factors are calculated from different principles. Electronic factor is determined by the quantum-mechanical method from the molecular pseudopotential, whereas the information
    [...] Read more.
    The biological activity of chemical compounds is analyzed using electronic and information factors. We found a linear interrelation between the electronic and information factors of molecules. Moreover, these molecular factors are calculated from different principles. Electronic factor is determined by the quantum-mechanical method from the molecular pseudopotential, whereas the information factor is determined by using the information function. It is shown that these factors are separated off statistically significant bioactive chemical compounds of inactive chemicals. To determine these factors is sufficient to know only the chemical formula of molecules. We analyzed the chemical compounds for toxicity, antiradiation activity, carcinogenicity, antifungal activities. To identify biologically active chemical compounds we used the statistical conjugation method of qualitative attributes.  Full article
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(3), 124-132. http://doi.org/10.31586/Biochemistry.0303.04
    83 Views 58 Downloads PDF Full-text (921.556 KB)  HTML Full-text
    Abstract
    The bone health is an important part of healthy-life and longevity in current situation due to huge toxins and contaminants in the environment and food chain. Considering the importance of bone health in the modern era, the present study was undertaken to investigate the effect of the Consciousness Energy
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    The bone health is an important part of healthy-life and longevity in current situation due to huge toxins and contaminants in the environment and food chain. Considering the importance of bone health in the modern era, the present study was undertaken to investigate the effect of the Consciousness Energy Healing (The Trivedi Effect?) Treatment on Dulbecco's Modified Eagle Medium (DMEM) in which the human bone osteosarcoma cells - MG-63 (ATCC? CRL-1427?) was grown for the assessment of bone cell proliferation and differentiation in vitro. The study parameters were assessed using cell viability by MTT assay, alkaline phosphatase (ALP), and collagen synthesis on bone health using ELISA-based assay. The cell viability was significantly increased by 24% in the Biofield Energy Treated group supplemented with 10% charcoal-dextran with fetal bovine serum (CD-FBS) (G3) compared to the untreated cells group (G1). The level of ALP was significantly increased by 72% in the G3 group compared to the G1 group. Additionally, the level of collagen synthesis was significantly (p?0.001) increased by 19% in the G3 group compared to the G1 group. The overall results demonstrated that the Biofield Energy Treated DMEM has the potential for bone mineralization and bone cells growth as evident via increased levels of collagen and ALP. Therefore, the Biofield Energy Healing (The Trivedi Effect?) Treatment could be useful as a bone health promoter for various bone-related disorders like low bone density, osteogenesis imperfecta, and osteoporosis, etc.  Full article
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(4), 151-160. http://doi.org/10.31586/Biochemistry.0304.02
    14 Views 8 Downloads PDF Full-text (1.084 MB)  HTML Full-text
    Abstract
    The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophylactic and curative activity of the studied plant was accessed after oral administration of standard drugs (5mgkg-1 choroquine and 4mgkg-1 artesunate)
    [...] Read more.
    The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophylactic and curative activity of the studied plant was accessed after oral administration of standard drugs (5mgkg-1 choroquine and 4mgkg-1 artesunate) and 400-800mgkg-1 of the extract. The effect of the aqueous leaf extract of the studied plant was also explored in the activities of liver enzymes, oxidative stress markers and hematological indices of plasmodium infected mice using spectrophotomertic methods and a hematology auto analyzer (BC 5300 Mindray England) respectively. The aqueous leaf extract of Justicia carnea showed considerable dose dependent antiplasmodial activity in the suppressive, prophylactic and curative test conducted. The suppressive activity of (92%) of the aqueous leaf extract of the studied plant at 800mgkg-1 was comparable to the standard drugs used while the mean survival time of plasmodium infected mice at 800mgkg-1 was beyond the mean survival time of the infected untreated group. The aqueous leaf extract of the studied plant also exhibited significant improvements in the activities of liver enzymes, oxidative stress markers and some hematological parameters at 800mgkg-1 of the extract when compared with the infected and untreated group. The results of the study exhibited the antiplasmodial activity of the studied plant, nonetheless, the crude extracts of the studied plant can be further purified for synergistic use with other potent antimalarial drugs to combat and achieve total clearance of plasmodium resistant infections.  Full article
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