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Keywords = cholesterol

  • Open Access Research Article
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    Trends Journal of Sciences Research 2015, 2(4), 126-133. http://doi.org/10.31586/CardiovascularDisease.0204.03
    10 Views 79 Downloads 1 Citations PDF Full-text (882.186 KB)  HTML Full-text
    Abstract
    Cardiovascular disease (CVD) is a leading cause of further morbidity and mortality in type 2 diabetes patients. This study aimed to find the serum lipid profile, serum uric acid levels, other CVD risk factors, and how these factors are affected by diabetes duration in adults with type 2 diabetes. The
    [...] Read more.
    Cardiovascular disease (CVD) is a leading cause of further morbidity and mortality in type 2 diabetes patients. This study aimed to find the serum lipid profile, serum uric acid levels, other CVD risk factors, and how these factors are affected by diabetes duration in adults with type 2 diabetes. The cross- sectional study, involving 100 subjects, was carried out at the Diabetes Centre, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana. Adult type 2 diabetes patients, 20 years or older, were recruited for the study. The National Cholesterol Education Program (NCEP) Adult Panel III and American Diabetes Association (ADA) guidelines were used to find the metabolic status of the patients. Of the 100 patients, 74% and 62% had high systolic blood pressure and abdominal obesity, respectively. Also, high LDL-cholesterol and hypercholesterolaemia were found in 47% and 46% of the patients, respectively. Forty-six percent (46%) of the patients were hyperuricaemic. Cardiovascular disease risk increased with age from 20 to 79 years. The female diabetics had more adverse CVD risk profile than the male diabetics (high LDL, 55% vs. 23.1%; high total cholesterol, 54.1% vs. 23.1%; high triglycerides, 32.4% vs. 30.8%; low HDL, 25.7% vs. 3.8%). Fifty percent (50%) of females compared to 34.6% of males were hyperuricaemic. However, hypertension was more prevalent among males (systolic blood pressure, 76.9%; diastolic blood pressure, 38.5%) than among females (systolic blood pressure, 73%; diastolic blood pressure, 37.8%). In conclusion, the prevalence of hyperuricaemia and other cardiometabolic risks was high among type 2 diabetes patients.  Full article
    References
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(3), 133-137. http://doi.org/10.31586/Psychiatry.0303.05
    221 Views 91 Downloads PDF Full-text (686.826 KB)  HTML Full-text
    Abstract
    Objective: Suicide is the most common cause of premature death of schizophrenia. This study investigated the relationship between cholesterol levels and suicidal behaviour in chronic psychosis. Methods: The study group consisted of 109 schizophrenia, schizoaffective and other non affectice psychosis defined by Diagnostic and Statistical Manual of Mental Disorders, 5th
    [...] Read more.
    Objective: Suicide is the most common cause of premature death of schizophrenia. This study investigated the relationship between cholesterol levels and suicidal behaviour in chronic psychosis. Methods: The study group consisted of 109 schizophrenia, schizoaffective and other non affectice psychosis defined by Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) criteria. Lifetime suicide attempts of patients were retrospectively screened. The patients were divided into two groups with and without suicide. Serum cholesterol levels were compared between two groups. Results: The mean total cholesterol, triglyceride, HDL and LDL levels were 163.8 mg/dl,150.8 mg/dl,40.8 mg/dl and 132.4 mg/dl, respectively in the study group while they were 197.1 mg/dl, 194 mg/dl, 44.9 mg/dl and 124.2 mg/dl, respectively in the control group. Total cholesterol levels were significantly lower than patients with suicidal attempts compared with the patients with no suicidal attemps (p=0,03). No association was found between suicidal attempt and HDL cholesterol (p=0,24), triglyceride (p=0,193), and LDL(p=0,45). Conclusion: This result supports the hypothesis of association low plasma cholesterol levels and suicidal behavior in psychosis  Full article
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2019, 4(1), 21-28. http://doi.org/10.31586/Cardiology.0401.04
    80 Views 95 Downloads PDF Full-text (793.318 KB) PDF Full-text (794.026 KB) PDF Full-text (793.965 KB)  HTML Full-text
    Abstract
    At present, cardiovascular diseases are global health problems responsible for 17.3 million deaths per year and adding extra burden in developing countries like Nepal. Studies show that serum uric acid (SUA) can result in endothelial dysfunction which can lead to vascular disease like stroke. In this study, we determined serum
    [...] Read more.
    At present, cardiovascular diseases are global health problems responsible for 17.3 million deaths per year and adding extra burden in developing countries like Nepal. Studies show that serum uric acid (SUA) can result in endothelial dysfunction which can lead to vascular disease like stroke. In this study, we determined serum uric acid levels in patients with acute coronary syndrome (ACS) and assess its risk factors. A cross sectional study was conducted in 82 patients with ACS who fulfilled the inclusion criteria included in the study and their serum uric acid level were investigated. It was found that 51 (62.2%) were males and 31 (37.8%) were females. Mean age in study population was 60.26 ± 11.34 years. Majority of the population belongs to 56-65 years age group. The mean uric acid level of our study population was 6.03 ± 1.50 mg/dl (male = 5.92 ± 1.72, female = 6.64 ± 1.53). SUA ≥ 7 mg/dl was maximum in 56-65 years age group and there was no association between age and SUA (P value = 0.146). Over half of the study population were hypertensive i.e. 42 (51.21%) and smoker i.e. 43 (52.43%). It showed association between SUA and ACS (P value = 0.003). Among those having diabetes, maximum have SUA ≥ 7 mg/dl i.e. 17 (47.22%). Among those having high cholesterol level, male have higher incidence than female with no association between T. Cholesterol and gender (P value = 0.49). The mean value of T. Cholesterol was 189.83 ± 46.81 mg/dl (male = 198.78 ± 55.19 mg/dl, female = 202.30 ± 54.92 mg/dl) with (P value = 0.52). In conclusion, the mean age of ACS patients was 60.26 years, with the peak incidence at the age of 56-65 years. The ACS had male predominance. The potential risk factors of ACS were: Age >56 years (65.83%), male sex (62.2%), dyslipidemia (35.36%, hypertension (51.2%), diabetes mellitus (43.9%), smoking (52.4%) and alcohol consumption (39%). Among these SUA significantly associated with risk factors were- Sex, Diabetes Mellitus, T. Cholesterol. There was association between serum uric acid level and ACS patients. Hypertension and smoking constitutes one of the major risk factor for ACS in study population.  Full article
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2019, 4(4), 127-140. http://doi.org/10.31586/Hepatology.0401.01
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    Abstract
    Introduction: Liver and kidney affection is a life-threatening disease caused by factors including drug-based treatment. Treatment based on methotrexate could result in liver and kidney damages. The study evaluates the preventive effects of Sorindeia juglandifolia leaves on methotrexate-induced liver and kidney impairment in rat. Methods: Healthy rats divided into 6
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    Introduction: Liver and kidney affection is a life-threatening disease caused by factors including drug-based treatment. Treatment based on methotrexate could result in liver and kidney damages. The study evaluates the preventive effects of Sorindeia juglandifolia leaves on methotrexate-induced liver and kidney impairment in rat. Methods: Healthy rats divided into 6 groups daily received distilled water, methotrexate (20 mg/kg), sub-cutaneous injection of L-carnitin (500 mg/kg) and methotrexate and the plant extract doses of 150, 250 and 350 mg/kg and methotrexate for 10 days. During treatment, body weight was recorded. At the end of the treatment, animals were sacrificed; venous blood were collected for haematological and biochemical analysis. Liver and kidney were collected for oxidative markers and histological examination. Results: The consecutive treatment of animals with plant extract and methotrexate showed a significant prevention of the body weight decrease and enhancement of the relative weight of liver and kidney. Sorindeia. juglandifolia extract also protected from the significant increase in transaminase activities, bilirubin and protein level, hypercholesterolemia, atherogenic index, and in the kidney from hypercreatininemia and the increase in serum urea level. The extract prevented the decrease of sodium level and glomerular filtration. Plant extract improved reactive oxygen species detoxification agents and protected from the histological disorganization of the liver and kidney tissues, observed in the MTX control. Conclusion: Sorindeia juglandifolia leaves extract expressed hepatorenal protective properties and could be useful to prevent liver and kidney damage induce by methotrexate.  Full article
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