• Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(2), 82-89. 10.31586/AnalyticalChemistry.0302.04
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    Abstract
    In this research, a new nano graphene oxide based solid phase extraction followed by Dispersive Liquid-Liquid Microextraction was applied as simple, rapid and sensitive determination of trace amounts of Propranolol(PRO) in urine samples with HPLC-UVD. Several factors influencing the extraction of PRO, such as pH, adsorbent amounts, extraction time, organic
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    In this research, a new nano graphene oxide based solid phase extraction followed by Dispersive Liquid-Liquid Microextraction was applied as simple, rapid and sensitive determination of trace amounts of Propranolol(PRO) in urine samples with HPLC-UVD. Several factors influencing the extraction of PRO, such as pH, adsorbent amounts, extraction time, organic solvent type and the composition of solvent and desorption conditions were studied and optimized. Under optimum condition, the limit of detection (LOD) and limit of quantification (LOQ) of the proposed method were 2ng/mL?1 and 6.6ng/mL, respectively. Good linear behaviour over the investigated concentration ranges (2-2000ng/mL-1) and good correlation coefficient of 0.9901(r2) were obtained. The relative standard deviations (RSDs) based on three determinations at 2, 20, 200ng/ml-1 levels of PRO was less than 9.7 %. The findings of the present study may provide clinical and diagnostic laboratories.Full article
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(2), 60-68. 10.31586/Cancer.0302.01
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    Abstract
    Objective: To evaluate the efficacy and safety of nimotuzumab in combination with radiochemotherapy as the primary treatment in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Methods: We retrospectively reviewed patients with locoregionally advanced nasopharyngeal carcinoma from September 2012 to December 2016. 188 newly diagnosed patients with stage III?IVB nasopharyngeal carcinoma
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    Objective: To evaluate the efficacy and safety of nimotuzumab in combination with radiochemotherapy as the primary treatment in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Methods: We retrospectively reviewed patients with locoregionally advanced nasopharyngeal carcinoma from September 2012 to December 2016. 188 newly diagnosed patients with stage III?IVB nasopharyngeal carcinoma were treated with at least 1-2 cycles of chemotherapy concurrently with planned IMRT. 88 patients received nimotuzumab 200 mg/week. Acute and late radiation-related toxicities were graded according to the Acute and Late Radiation Morbidity Scoring Criteria of Radiation Therapy Oncology Group. Results: After 3 months of treatment, the complete response rates of nasopharyngeal tumors in the study group and the control group were 78.4% and 65.5%, respectively (?2=4.070, P=0.044). The total complete response rates of cervical lymph nodes in the study group and the control group were 80.7% and 67.6% respectively (?2=4.022, P=0.045).The median cycle for nimotuzumab addition was 6.3 weeks. With a median follow-up of 36.3 months (range, 12?72 months), the estimated 3-year progression failure-free survival and overall survival rates for the study group and the control group were 85.24% vs 81.97% and 96.67% vs 90.0%, respectively. The 3-year local recurrence-free survival rates for the study group and the control group were 96.67% vs 83.60%, respectively (P=0.047). Grade 3 radiation-induced mucositis accounted for 36.4% of treated patients. No skin rash and infusion reaction were observed, distinctly from what is reported in control patients. Conclusion: Nimotuzumab plus chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma showed promising outcomes in terms of locoregional control, without increasing the incidence of radiation-related toxicities for patients.Full article
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  • Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(2), 90-95. 10.31586/Biology.0302.05
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    Abstract
    Salinity is one of the important abiotic stress affecting microorganism growth and productivity. To survive these stresses most organisms have to stress-adaptation mechanisms. It's one of these things proline. We did not find any similar studies with P. aeruginosa and E. faecalis in our studies. The highest value for proline
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    Salinity is one of the important abiotic stress affecting microorganism growth and productivity. To survive these stresses most organisms have to stress-adaptation mechanisms. It's one of these things proline. We did not find any similar studies with P. aeruginosa and E. faecalis in our studies. The highest value for proline production at 30 ?C 100 rpm was in E. faecalis 11,074 U/ml and in E. coli 6,833 U/ml. The highest proline production in LB medium containing 37 ?C 100 rpm KCl was found to be in E. faecalis 14,604 U/ml and in E. coli 6,557 U/ml. However, there are studies with E. coli. This experiment revealed that the extracellular proline concentration is proportionally linked to the KCl stress. We should first mention that studies similar to those we were less common in the literature. We did not find any similar studies with P. aeruginosa and E. faecalis in our studies.Full article
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  • Open Access Mini Review
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    Trends Journal of Sciences Research 2018, 3(2), 75-81. 10.31586/Nursing.0302.03
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    Abstract
    Genotype and lifestyle factors have been implicated as the causes of non-communicable diseases including diabetes, cardiovascular diseases, cancer and chronic respiratory disease. Lifestyle factors constitute physical activity, smoking, alcohol intake and dietary habits. These factors alongside genetic factors have been studied over the past years on their relationships with non-communicable
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    Genotype and lifestyle factors have been implicated as the causes of non-communicable diseases including diabetes, cardiovascular diseases, cancer and chronic respiratory disease. Lifestyle factors constitute physical activity, smoking, alcohol intake and dietary habits. These factors alongside genetic factors have been studied over the past years on their relationships with non-communicable diseases. This review examined and compared the strengths of the two factors, lifestyle and genotype, in causing non-communicable diseases. A search was done online, predominantly with PubMed, to identify articles that contained the keywords, lifestyle, diet, exercise, genotype, gene, non-communicable diseases, cardiovascular diseases, cancer, chronic respiratory disease, diabetes. For diabetes, the results of this review showed that management of lifestyle factors can be used to prevent type 2 diabetes among genetically predisposed persons. Cancers studies have suggested that a Mediterranean diet is associated with lower cancer risk for both genetically susceptible people and non-susceptible individuals. Similar findings were gotten for cardiovascular diseases and chronic respiratory diseases. The results suggest a strong impact of lifestyle-related factors as a cause of non-communicable diseases though genetic factors cannot be underestimated. With good management of lifestyle factors, non-communicable diseases can be prevented and the risks reduced even among genetically high-risk individuals.Full article
  • Open Access Research Article
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    Trends Journal of Sciences Research 2018, 3(2), 69-74. 10.31586/Physiology.0302.02
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    Abstract
    Heat stress can affect reproduction potential as an environmental factor. This Study was carried out to investigate the effects of rosemary extract on spermatogenesis and sexual hormones of laboratory mice under heat stress. 50 male mature mice were examined in five groups including a control group and four experimental groups
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    Heat stress can affect reproduction potential as an environmental factor. This Study was carried out to investigate the effects of rosemary extract on spermatogenesis and sexual hormones of laboratory mice under heat stress. 50 male mature mice were examined in five groups including a control group and four experimental groups [0, 100, 200 and 400 mg/kg of rosemary extract]. Samples were kept under heat stress four hours a day and received the extract doses for 30 days. At the end of the experiment, the amount of testosterone, LH, and FSH hormones plus the number of spermatogenic cells were measured. Obtained data were analyzed using the SPSS program. Heat stress in zero doses reduced testosterone, LH, and FSH significantly whereas rosemary extract increased testosterone and LH in 200 and 400 doses and FSH in 100,200, and 400 doses. Primary spermatocytes were decreased in zero doses significantly but increased significantly in other experimental groups [p<0.05]. In general, Heat stress reduces male sex hormones and spermatogenic cells but rosemary extract compensated this reduction dose-dependently and improved sexual potential under heat stress.Full article
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  • Open Access Case Report
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    Trends Journal of Sciences Research 2018, 3(2), 96-103. 10.31586/Surgery.0302.06
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    Abstract
    Primary cardiac tumors are rare with an incidence ranging from 0.001% to 0.03% in autopsy series. The prognosis of cardiac sarcomas remains poor because it proliferates rapidly, and distant metastases are often found at diagnosis. We present a case of liposarcoma in the atrium of the heart as case report
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    Primary cardiac tumors are rare with an incidence ranging from 0.001% to 0.03% in autopsy series. The prognosis of cardiac sarcomas remains poor because it proliferates rapidly, and distant metastases are often found at diagnosis. We present a case of liposarcoma in the atrium of the heart as case report and same time,we do a literature review about it.Case Report: We present the case of a 30-year-old female with a significant tumor of cardiac liposarcoma, with chief complaint of dyspnea, tachycardia and heart failure even angina pectoris.Conclusion: The diagnostician?s differential diagnosis must be broad when encountering common chief complaints, such as tachycardia, heart failure and angina pectoris.Full article
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