Research Article | Open Access | 10.31586/Psychiatry.0303.05

Relationship between Cholesterol Levels and Suicide Attempts in Chronic Psychosis

Cholesterol Levels and Suicide Attempts in Chronic Psychosis

  • Ahmet Ziya Sahin1,*, Sengul Sahin2 and Sakir Ozgur Keskek3
    Department of Internal Medicine, Cukurova State Hospital, Turkey
    Department of Medical Faculty, Gaziantep University, Turkey
    Department of Internal Medicine, Adana Rerearch and Training Hospital, Turkey



Suicide is the most common cause of premature death of schizophrenia. This study investigated the relationship between cholesterol levels and suicidal behaviour in chronic psychosis


The study group consisted of 109 schizophrenia, schizoaffective and other non affectice psychosis defined by Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-V) criteria. Lifetime suicide attempts of patients were retrospectively screened. The patients were divided into two groups with and without suicide. Serum cholesterol levels were compared between two groups. Results:The mean total cholesterol, triglyceride, HDL and LDL levels were 163.8 mg /dl,150.8 mg /dl,40.8 mg /dl and 132.4 mg/dl, respectively in the study group while they were 197.1 mg / dl, 194 mg / dl, 44.9 mg / dl and 124.2 mg/dl, respectively in the control group. Total cholesterol levels were significantly lower than patients with suicidal attempts compared with the patients with no suicidal attemps (p=0,03). No association was found between  suicidal attempt and HDL cholesterol (p=0,24), triglyceride (p=0,193), and LDL(p=0,45).  Conclusion:This result supports the hypothesis of association low plasma cholesterol levels and suicidal behavior in psychosis


Palmer BA, Pankratz VS, Bostwick JM. The life time risk of suicide in schizophrenia: a reexamination. Arch Gen Psychiatry. 2005; 62:247-253
Shrivastava A, Shah N, Johnston M, Stitt L, Thakar M. Predictors of long-termoutcome of first-episode schizophrenia: A ten-year follow-up study. Indian J Psychiatry. 2010; 52:320?326
Barak Y, Baruch Y, Achiron A, Aizenberg D. Suicide attempts of schizophrenia patients: a case-controlled study in tertiary care. J PsychiatrRes. 2008; 42:822-826.
Pompili M, Serafini G, Innamorati M, Lester D, Shrivastava A, Girardi P, Nordentoft M. Suicide risk in first episode psychosis: A selective review of the current literature. Schizophr Res. 2011;129:1?11.
Goldacre M, Seagroatt V, Hawton K. Suicide after discharge from psychiatric inpatient care. Lancet. 1993;342:283?6
Ainiyet B, Rybakowski JK. Suicidal behavior in schizophrenia may be related to low lipid levels. Med Sci Monit. 2014;20:1486?1490
Kim YK, Lee HJ, Kim JY, Yoon DK, Choi SH, Lee MS. Low serum cholesterol is correlated to suicidality in a Korean sample. Acta Psychiatr Scand. 2002;105:141?148.
Ernst C, Mechawar N, Turecki G. Suicide neurobiology. Prog Neurobiol. 2009;89:315?333
Lalovic A, Levy E, Luheshi G, Canetti L, Grenier E, Sequeira A, Turecki G. Cholesterol content in brains of suicide completers. Int J Neuropsychopharmacol. 2007;10:159?166
Uzun O, Tamam L, Ozculer T, Doruk A, Unal. Specific characteristics of suicide attempts in patients with schizophrenia in Turkey. Isr J Psychiatry Relat Sci. 2009;46:189-194.
Atmaca M, Kuloglu M, Tezcan E, Ustundag B. Serum leptin and cholesterol levels in schizophrenic patients with and without suicide attempts. Acta Psychiatr Scand. 2003;108:208?214.
Marcinko D, Martinac M, Karlovi? D, Loncar C. Cholesterol serum levels in violent and non-violent young male schizophrenic suicide attempters. Psychiatr Danub. 2004;16:161?164.
Marcinko D, Martinac M, KarloviC D, Filipci? I, Loncar C, Pivac N, Jakovljevi? M. Are there differences in serum cholesterol and cortisol concentrations between violent and non violent schizophrenic male suicide attempters? CollAntropol. 2005;29:153?157.
Tarrier N, Khan S, Cater J, Picken A. The subjective consequences of suffering a firs tepisode psychosis: Trauma and suicide behaviour. Soc Psychiatry Psychiatr Epidemiol. 2007;42:29?35
Shrivastava A, Johnston M, Campbell R, Sousa AD, Shah N. Serum cholesterol and Suicide in first episode psychosis: A preliminary Study. Indian J Psychiatry. 2017; 59: 478?482.
Lester D. Serum cholesterol levels and suicide: A meta-analysis. Suicide Life Threat Behav. 2002;32:333?46
Freemantle E, Chen GG, Cruceanu C, Mechawar N, Turecki G. Analysis of oxysterols and cholesterol in prefrontal cortex of suicides. Int J Neuro-psychopharmacol. 2013;16:1241?1244
Papakostas GI, Petersen T, Mischoulon D, Hughes ME, Alpert JE, Nierenberg AA, Rosenbaum JF, Fava M. Serum cholesterol and serotonergic function in maj?r depressive disorder. PsychiatryRes. 2003;9:137?145


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October 10, 2018
How to Cite
SAHIN, Ahmet Ziya; SAHIN, Sengul; KESKEK, Sakir Ozgur. Relationship between Cholesterol Levels and Suicide Attempts in Chronic Psychosis. Trends Journal of Sciences Research, [S.l.], v. 3, n. 3, p. 133-137, oct. 2018. ISSN 2377-8083. Available at: <>. Date accessed: 21 july 2019.