Research Article | Open Access | 10.31586/Cardiology.0401.04

Study of Serum Uric Acid Level in Acute Coronary Syndrome in Nepalese Subjects


At present, cardiovascular diseases are global health problems responsible for 17.3 million deaths per year and adding extra burden in developing countries like Nepal. Studies show that serum uric acid (SUA) can result in endothelial dysfunction which can lead to vascular disease like stroke. In this study, we determined serum uric acid levels in patients with acute coronary syndrome (ACS) and assess its risk factors. A cross sectional study was conducted in 82 patients with ACS who fulfilled the inclusion criteria included in the study and their serum uric acid level were investigated. It was found that 51 (62.2%) were males and 31 (37.8%) were females. Mean age in study population was 60.26 ± 11.34 years. Majority of the population belongs to 56-65 years age group. The mean uric acid level of our study population was 6.03 ± 1.50 mg/dl (male = 5.92 ± 1.72, female = 6.64 ± 1.53). SUA ≥ 7 mg/dl was maximum in 56-65 years age group and there was no association between age and SUA (P value = 0.146). Over half of the study population were hypertensive i.e. 42 (51.21%) and smoker i.e. 43 (52.43%). It showed association between SUA and ACS (P value = 0.003). Among those having diabetes, maximum have SUA ≥ 7 mg/dl i.e. 17 (47.22%). Among those having high cholesterol level, male have higher incidence than female with no association between T. Cholesterol and gender (P value = 0.49). The mean value of T. Cholesterol was 189.83 ± 46.81 mg/dl (male = 198.78 ± 55.19 mg/dl, female = 202.30 ± 54.92 mg/dl) with (P value = 0.52). In conclusion, the mean age of ACS patients was 60.26 years, with the peak incidence at the age of 56-65 years. The ACS had male predominance. The potential risk factors of ACS were: Age >56 years (65.83%), male sex (62.2%), dyslipidemia (35.36%, hypertension (51.2%), diabetes mellitus (43.9%), smoking (52.4%) and alcohol consumption (39%). Among these SUA significantly associated with risk factors were- Sex, Diabetes Mellitus, T. Cholesterol. There was association between serum uric acid level and ACS patients. Hypertension and smoking constitutes one of the major risk factor for ACS in study population.


Brosius FC, Hostetter TH, Kelepouris E, Mitsnefes MM, Moe SM, Moore MA, Pennathur S, Smith GL, Wilson PW. Detection of Chronic Kidney Disease in Patients with or at Increased Risk of Cardiovascular Disease. Hypertension 2006;48(4):751-5.
Friedlander Y, Kark JD, Stein Y. Family history of myocardial infarction as an independent risk factor for coronary heart disease. Heart 1985;53(4):382-7.
Sharaf El Din UAA, Salem MM, Abdulazim DO. Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review. J Adv Res 2017;8(5): 537–548.
Maria Lorenza Muiesan, Claudia Agabiti-Rosei, Anna Paini, Massimo Salvetti. Uric Acid and Cardiovascular Disease: An Update. 2016;11(1):54–59.
Squadrito GL, Cueto R, Splenser AE, Valavanidis A, Zhang H, Uppu RM, Pryor WA. Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. Arch Biochem Biophys 2000;376(2):333-7.
Nieto FJ, Iribarren C, Gross MD, Comstock GW, Cutler RG. Uric acid and serum antioxidant capacity: a reaction to atherosclerosis? Atherosclerosis 2000;148(1):131-9.
Daskalopoulou SS, Athyros VG, Elisaf M, Mikhailidis DP. Uric acid levels and vascular disease. Curr Med Res Opin 2004;20(6):951-4.
Lehto S, Niskanen L, Rönnemaa T, Laakso M. Serum uric acid is a strong predictor of stroke in patients with non–insulin-dependent diabetes mellitus. Stroke 1998;29(3):635-9.
Kutzing MK, Firestein BL. Altered uric acid levels and disease states. J Pharmacol Exp Ther 2008;324(1):1-7.
Paudel B, Paudel K. Western Nepal acute coronary syndrome (WestNP-ACS) registry: Characteristics, management and in-hospital outcome of patients admitted with acute coronary syndrome in western Nepal. J GMC Nepal 2009;2(3):51-9.
Khatri P, Simkhada R. Study on conventional risk factors in acute coronary syndrome. J Universal College Med Sci. 2016;3(2):1-4.
Sinan Deveci O, Kabakci G, Okutucu S, Tulumen E, Aksoy H, Baris Kaya E, Evranos B, Aytemir K, Tokgozoglu L, Oto A. The association between serum uric acid level and coronary artery disease. Int J Clin Pract 2010;64(7):900-7.
Man KC, Rajbhandari S, Sharma D, Malla R, Rajbhandari R, Limbu Y, Regmi S, Maskey A. Distribution of Risk Factors in Patients with Acute Coronary Syndrome-A Hospital Based Study. J Nepal Med Assoc 2003;42(148);216-219.
Dali B. Clinical Profile, Dyslipidemia and ACS - a Correlation. J Nepal Med Assoc 2014;52(195):907-13.
Brand FN, McGee DL, Kannel WB, STOKES III J, Castelli WP. Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study. Am J Epidemiol 1985;121(1):11-8.
Hasic S, Kadic D, Kiseljakovic E, Jadric R, Spahic E. Serum Uric Acid Could Differentiate Acute Myocardial Infarction and Unstable Angina Pectoris in Hyperuricemic Acute Coronary Syndrome Patients. Med Arch 2017;71(2):115-118.
Lim HE, Kim SH, Kim EJ, Kim JW, Rha SW, Seo HS, Park CG. Clinical value of serum uric acid in patients with suspected coronary artery disease. Korean J Intern Med 2010;25(1):21–26.


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January 11, 2019
How to Cite
KARKI, Manoj et al. Study of Serum Uric Acid Level in Acute Coronary Syndrome in Nepalese Subjects. Trends Journal of Sciences Research, [S.l.], v. 4, n. 1, p. 21-28, jan. 2019. ISSN 2377-8083. Available at: <>. Date accessed: 21 jan. 2019.